Fran Siegel has developed and exhibited work throughout Europe and South America. As a Fulbright fellow in Brazil, she conducted research for Lineage Through Landscape which was included in Getty's city-wide initiative PST- Los Angeles/Latin America with her 2017 solo exhibition at The UCLA Fowler Museum. In 2024 her project In Flux was included in Getty's PST- Art and Science Collide. In 2025 she was awarded a second Fulbright to Portugal. Residency fellowships inform her location-based practice and include: The Bogliasco Foundation and Siena Art Institute in Italy; La Napôule and Camargo/Bau Foundation in France; CCA Andrax, Spain; and Instituto Sacatar, Bahia, Brazil. Siegel represented the United States in the IX International Biennial of Cuenca, Ecuador and Art in Embassies commissioned a permanent work for the U.S. consulate in Guayaquil, Ecuador. 

Siegel received grants from the California Community Foundation, Los Angeles Individual Artist C.O.L.A., Center for Cultural Innovation, and the OC Contemporary Collectors Grant. She earned her M.F.A. from Yale University School of Art, and B.F.A. from Tyler School of Art. Siegel's works are in public collections at Los Angeles County Museum of Art, Los Angeles, CA; The Museum of Contemporary Art, Los Angeles, CA; Art, Design & Architecture Museum, Santa Barbara, CA; Long Beach Museum of Art, Long Beach, CA; Yale University Art Gallery, New Haven, CT, and The Morgan Library Museum, New York, NY.